Nitric Oxide

Nitric Oxide Production and Nitric Oxide

Nitric oxide and the bioactivities

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...

Is Nitric Oxide a Hormone?

Nitric oxide (NO) is a simple ubiquitous signaling molecule and plays important roles in almost every biological system. Recent evidences suggest that NO may act as an endocrine molecule. The aim of this review is considering available literature on endocrine roles of NO and/or its metabolites, i.e. nitrite and nitrate. Existing data suggest the idea that NO is a hormone that after production i...

Nitric oxide and the bioactivities

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...

Perspective Series: Nitric Oxide and Nitric Oxide Synthases Nitric Oxide Synthases: Which, Where, How, and Why?

Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present in all mammalian cells, the sheer volume of publications on the subject might lead one to conclude that this diminutive molecule is both omnipotent and omnipresent in human biology. This series of four Perspective articles, in the current and following issues of The Journal of Clinical Investigation , wi...